This research investigates why individuals respond differently to the same diet. The lab studies genetic variation, gut microbiome composition, hormone signaling, and lifestyle factors to understand how they shape nutrient metabolism and energy balance. By integrating metabolomics, microbiome sequencing, and clinical data, researchers aim to predict how a person will respond to specific macronutrient ratios or dietary patterns. The long-term goal is to develop precision nutrition frameworks that optimize metabolic health, prevent chronic disease, and improve clinical dietary interventions.