This topic focuses on how cells detect and respond to nutrient availability through molecular signaling pathways such as mTOR, AMPK, and insulin signaling cascades. The lab examines how dysregulation of these pathways contributes to metabolic disorders including obesity, type 2 diabetes, and fatty liver disease. Using cellular models, animal studies, and human clinical samples, researchers map how nutrient excess or deficiency alters metabolic signaling networks. This work supports development of targeted therapies that restore metabolic homeostasis rather than only treating symptoms.